Shikonine
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Nom de la substance
Shikonine
Famille moléculaire
- Pigment rouge du groupe des naphtoquinones
Source végétale
Propriétés
- Utilisé comme colorant
- Anti-inflammatoire
- Inhibiteur de la glycolyse
- Inhibiteur de l'adipogenèse [1]
- Antitumoral [2], [3], toxique pour les cellules cancéreuses [1]
- Immunostimulant [4]
Effet thérapeutique
Effets indésirables
Bibliographie
- ↑ Gwon SY, Ahn JY, Jung CH, Moon BK, Ha TY. Shikonin suppresses ERK 1/2 phosphorylation during the early stages of adipocyte differentiation in 3T3-L1 cells. BMC Complementary and Alternative Medicine 2013, 13:207 (6 August 2013) Abstract Provisional PDF
- ↑ Wei PL, Tu CC, Chen CH, Ho YS, Wu CT, Su HY, Chen WY, Liu JJ, Chang YJ. Shikonin suppresses the migratory ability of hepatocellular carcinoma cells. J Agric Food Chem. 2013 Jul 31. PMID 23899086
- ↑ Gong K, Li W. Shikonin, a Chinese plant-derived naphthoquinone, induces apoptosis in hepatocellular carcinoma cells through reactive oxygen species: A potential new treatment for hepatocellular carcinoma. Free Radic Biol Med. 2011 Dec 15;51(12):2259-71. PMID 22011623
- ↑ Pietrosiuk A, Skopińska-Rózewska E, Furmanowa M, Wiedenfeld H, Sommer E, Sokolnicka I, Rogala E, Radomska-Leśniewska D, Bany J, Malinowski M. Immunomodulatory effect of shikonin derivatives isolated from Lithospermum canescens on cellular and humoral immunity in Balb/c mice. Pharmazie. 2004 Aug;59(8):640-2. PMID 15378856